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To further evaluate the potential influence of age on metabolite differences between MMA patients and healthy controls, analysis of covariance (ANCOVA) was performed with disease status (MMA versus control) included as the fixed factor and age as a covariate

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Maria Serrat reports grants from National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health and grants from National Institute of General Medical Sciences, during the conduct of the study

Oxalate activates autophagy to induce ferroptosis of renal tubular epithelial cells and participates in the formation of kidney stones

Each is an independently manufactured and tested reference compound, supplied as a lyophilised solid